Sunday, January 19, 2020

Pacemaker potential I SA node action potential I Cardiovascular physiology

In this video, we differentiate between SA node action potential and ventricular action potential. 

 SA node action potential is responsible for automaticity of heart. It consists of 3 phases : phase 4, phase 0 and phase 3.

Phase 4 is due to: Hyperpolarization gated cyclic nucleotide channels (HCN channels) and T type voltage gated calcium channels.

Phase 0 is due to opening of L type voltage gated calcium channels and entry of calcium inside the cells

Phase 3 is due toopening of voltage gated potassium channels and exit of potassium from the cells.

(Where are phases 1 and 2 ?) 😮

Phase 4 is also known as prepotential or pacemaker potential. The slope of the phase 4 determines the number of impulses which are generated in 1 minue. Steeper slope means more impulses, less steep slope means less impulses.

 

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